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To grow a body, cells in the embryo need to make many decisions about what to be and where to go. Should a cell become part of the brain or part of the gut? To coordinate these decisions across the embryo, cells communicate using cell signaling pathways. Receptors at the cell surface detect signaling ligands and activate biochemical reactions within the cell that ultimately turn on expression of specific genes. In our lab, we are most interested in how cells make quantitative measurements of these inputs and then use these measurements to make developmental decisions. We use a toolbox of light-activated proteins (optogenetics), novel biosensors, and genome editing in our favorite model system, the Drosophila fruit fly embryo.
To grow a body, cells in the embryo need to make many decisions about what to be and where to go. Should a cell become part of the brain or part of the gut? To coordinate these decisions across the embryo, cells communicate using cell signaling pathways. Receptors at the cell surface detect signaling ligands and activate biochemical reactions within the cell that ultimately turn on expression of specific genes. In our lab, we are most interested in how cells make quantitative measurements of these inputs and then use these measurements to make developmental decisions. We use a toolbox of light-activated proteins (optogenetics), novel biosensors, and genome editing in our favorite model system, the Drosophila fruit fly embryo.
Kolenbrander Ho Lab
Kravis Department of Integrated Sciences
Claremont McKenna College
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